CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidyl-prolyl cis-trans isomerase FKBP1A

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62942
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62942
FKB1A_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP1A

PDB Structure

PDB 1BKF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Conformation of Fk506 in X-Ray Structures of its Complexes with Human Recombinant Fkbp12 Mutants
Itoh, S., Decenzo, M.T., Livingston, D.J., Pearlman, D.A., Navia, M.A.
Bioorg.Med.Chem.Lett.