CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Complement factor D

Enzyme Information

3.4.21.46
Complement factor D.
based on mapping to UniProt P00746
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00746
CFAD_HUMAN
Homo sapiens
Complement factor D

PDB Structure

PDB 1BIO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
Jing, H., Babu, Y.S., Moore, D., Kilpatrick, J.M., Liu, X.Y., Volanakis, J.E., Narayana, S.V.
J.Mol.Biol.