CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38
Cathepsin K.
based on mapping to UniProt P43235
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235
CATK_HUMAN
Homo sapiens
Cathepsin K

PDB Structure

PDB 1BGO
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K
Desjarlais, R.L., Yamashita, D.S., Oh, H.J., Uzinskas, I.N., Erhard, K.F., Allen, A.C., Haltiwanger, R.C., Zhao, B.G., Smith, W.W., Abdel-Meguid, S.S., Dalessio, K., Janson, C.A., Mcqueney, M.S., Tomaszek, T.A., Levy, M.A., Veber, D.F.
J.Am.Chem.Soc.