CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00735
THRB_BOVIN
Bos taurus
Prothrombin
P02671
FIBA_HUMAN
Homo sapiens
Fibrinogen alpha chain

PDB Structure

PDB 1BBR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
Martin, P.D., Robertson, W., Turk, D., Huber, R., Bode, W., Edwards, B.F.
J.Biol.Chem.