CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione S-transferase P

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P19157
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P19157
GSTP1_MOUSE
Mus musculus
Glutathione S-transferase P 1

PDB Structure

PDB 1BAY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.
Vega, M.C., Walsh, S.B., Mantle, T.J., Coll, M.
J.Biol.Chem.