CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.120 | 6 Propeller | |
2.120.10 | Neuraminidase | |
2.120.10.10 |
Domain Context
CATH Clusters
Superfamily | 2.120.10.10 |
Functional Family |
Enzyme Information
3.2.1.18 |
Exo-alpha-sialidase.
based on mapping to UniProt P03474
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.
|
UniProtKB Entries (1)
P03474 |
NRAM_INBLE
Influenza B virus (B/Lee/1940)
Neuraminidase
|
PDB Structure
PDB | 1B9S |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site.
J.Mol.Biol.
|