CATH Classification

Domain Context

CATH Clusters

Superfamily DNA mismatch repair MutH/Restriction endonuclease, type II
Functional Family

Enzyme Information
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P04390
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes:

UniProtKB Entries (1)

Escherichia coli
Type-2 restriction enzyme EcoRV

PDB Structure

PDB 1B94
External Links
Organism Escherichia
Primary Citation
Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Thomas, M.P., Brady, R.L., Halford, S.E., Sessions, R.B., Baldwin, G.S.
Nucleic Acids Res.