CATH Domain 1b8uA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family	Malate dehydrogenase

Enzyme Information

1.1.1.37

Malate dehydrogenase.

based on mapping to UniProt Q9ZF99

(S)-malate + NAD(+) = oxaloacetate + NADH.

-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

MDH_AQUAR

Aquaspirillum arcticum

Malate dehydrogenase

PDB Structure

PDB	1B8U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum. Kim, S.Y., Hwang, K.Y., Kim, S.H., Sung, H.C., Han, Y.S., Cho, Y. J.Biol.Chem.