CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.70 | Glucose Permease (Domain IIA) |
|
2.70.70.10 | Glucose Permease (Domain IIA) |
Domain Context
CATH Clusters
| Superfamily | Glucose Permease (Domain IIA) |
| Functional Family | PTS system glucose-specific IIA component |
Enzyme Information
| 2.7.1.199 |
Protein-N(pi)-phosphohistidine--D-glucose phosphotransferase.
based on mapping to UniProt P20166
[Protein]-N(pi)-phospho-L-histidine + D-glucose(Side 1) = [protein]-L- histidine + D-glucose 6-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9. -!- Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.
|
UniProtKB Entries (1)
| P20166 |
PTG3C_BACSU
Bacillus subtilis subsp. subtilis str. 168
PTS system glucose-specific EIICBA component
|
PDB Structure
| PDB | 1AX3 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
High-resolution solution structure of Bacillus subtilis IIAglc.
Proteins
|