CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

Q27049
TRIA_MECPA
Meccus pallidipennis
Triabin
P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1AVG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.
Fuentes-Prior, P., Noeske-Jungblut, C., Donner, P., Schleuning, W.D., Huber, R., Bode, W.
Proc.Natl.Acad.Sci.USA