CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Vitamin K-dependent protein C

Enzyme Information

3.4.21.69
Protein C (activated).
based on mapping to UniProt P04070
Degradation of blood coagulation factors Va and VIIIa.
-!- One of the gamma-carboxyglutamic acid-containing coagulation factors. -!- Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P04070
PROC_HUMAN
Homo sapiens
Vitamin K-dependent protein C

PDB Structure

PDB 1AUT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The 2.8 A crystal structure of Gla-domainless activated protein C.
Mather, T., Oganessyan, V., Hof, P., Huber, R., Foundling, S., Esmon, C., Bode, W.
EMBO J.