CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family

Enzyme Information

2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P00509
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.

UniProtKB Entries (1)

P00509
AAT_ECOLI
Escherichia coli K-12
Aspartate aminotransferase

PDB Structure

PDB 1ARI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Substitution of apolar residues in the active site of aspartate aminotransferase by histidine. Effects on reaction and substrate specificity.
Vacca, R.A., Christen, P., Malashkevich, V.N., Jansonius, J.N., Sandmeier, E.
Eur.J.Biochem.