CATH Classification

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.8.1.12
Trypanothione-disulfide reductase.
based on mapping to UniProt P28593
Trypanothione + NADP(+) = trypanothione disulfide + NADPH.
-!- Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. -!- The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7). -!- Formerly EC 1.6.4.8.

UniProtKB Entries (1)

P28593
TYTR_TRYCR
Trypanosoma cruzi
Trypanothione reductase

PDB Structure

PDB 1AOG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.
Zhang, Y., Bond, C.S., Bailey, S., Cunningham, M.L., Fairlamb, A.H., Hunter, W.N.
Protein Sci.