CATH Classification

Domain Context

CATH Clusters

Superfamily Translation factors
Functional Family NADPH--cytochrome P450 reductase 1

Enzyme Information

1.6.2.4
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

UniProtKB Entries (1)

P00388
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase

PDB Structure

PDB 1AMO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.
Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S., Kim, J.J.
Proc.Natl.Acad.Sci.USA