CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P25910
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P25910
BLAB_BACFG
Bacteroides fragilis
Metallo-beta-lactamase type 2

PDB Structure

PDB 1A8T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase.
Toney, J.H., Fitzgerald, P.M., Grover-Sharma, N., Olson, S.H., May, W.J., Sundelof, J.G., Vanderwall, D.E., Cleary, K.A., Grant, S.K., Wu, J.K., Kozarich, J.W., Pompliano, D.L., Hammond, G.G.
Chem.Biol.