CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Salivary plasminogen activator gamma

Enzyme Information

3.4.21.68
T-plasminogen activator.
based on mapping to UniProt P98119
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P98119
URT1_DESRO
Desmodus rotundus
Salivary plasminogen activator alpha 1

PDB Structure

PDB 1A5I
External Links
Method X-RAY DIFFRACTION
Organism Mesocricetus
Primary Citation
Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.
Renatus, M., Stubbs, M.T., Huber, R., Bringmann, P., Donner, P., Schleuning, W.D., Bode, W.
Biochemistry