CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tissue-type plasminogen activator

Enzyme Information

3.4.21.68
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00750
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator

PDB Structure

PDB 1A5H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
Renatus, M., Bode, W., Huber, R., Sturzebecher, J., Prasa, D., Fischer, S., Kohnert, U., Stubbs, M.T.
J.Biol.Chem.