CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family 4-trimethylaminobutyraldehyde dehydrogenase isoform X1

Enzyme Information
Aldehyde dehydrogenase (NAD(+)).
based on mapping to UniProt P56533
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
-!- Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. -!- Formerly EC
Betaine-aldehyde dehydrogenase.
based on mapping to UniProt P56533
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
-!- In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. -!- This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. -!- In contrast, different enzymes are involved in the first reaction. -!- In plants, this reaction is catalyzed by EC, whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC or soluble EC -!- In some bacteria, betaine is synthesized from glycine through the actions of EC and EC

UniProtKB Entries (1)

Gadus morhua callarias
Betaine aldehyde dehydrogenase

PDB Structure

External Links
Primary Citation
Structure of betaine aldehyde dehydrogenase at 2.1 A resolution.
Johansson, K., El-Ahmad, M., Ramaswamy, S., Hjelmqvist, L., Jornvall, H., Eklund, H.
Protein Sci.