CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Blood coagulation factor II

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28504
HIR2_HIRME
Hirudo medicinalis
Hirudin-2

PDB Structure

PDB 1A3B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Skordalakes, E., Elgendy, S., Goodwin, C.A., Green, D., Scully, M.F., Kakkar, V.V., Freyssinet, J.M., Dodson, G., Deadman, J.J.
Biochemistry