CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I; Chain A, domain 3
Functional Family Mitochondrial DNA topoisomerase I

Enzyme Information

5.99.1.2
DNA topoisomerase.
based on mapping to UniProt P11387
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).

UniProtKB Entries (1)

P11387
TOP1_HUMAN
Homo sapiens
DNA topoisomerase 1

PDB Structure

PDB 1A36
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
A model for the mechanism of human topoisomerase I.
Stewart, L., Redinbo, M.R., Qiu, X., Hol, W.G., Champoux, J.J.
Science