CATH Classification

Domain Context

CATH Clusters

Superfamily DNA Topoisomerase I, domain 2
Functional Family Mitochondrial DNA topoisomerase I

Enzyme Information
DNA topoisomerase.
based on mapping to UniProt P11387
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC

UniProtKB Entries (1)

Homo sapiens
DNA topoisomerase 1

PDB Structure

PDB 1A36
External Links
Organism Spodoptera
Primary Citation
A model for the mechanism of human topoisomerase I.
Stewart, L., Redinbo, M.R., Qiu, X., Hol, W.G., Champoux, J.J.