CATH Classification

CATH Clusters

Superfamily 3.10.450.40
Functional Family Copper amine oxidase 1

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P12807
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P12807
AMO_PICAN
Ogataea angusta
Peroxisomal primary amine oxidase

PDB Structure

PDB 1A2V
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Crystallographic study of yeast copper amine oxidase.
Li, R., Chen, L., Cai, D., Klinman, J.P., Mathews, F.S.
Acta Crystallogr.,Sect.D