CATH Classification

Domain Context

CATH Clusters

Superfamily Methylesterase CheB, C-terminal domain
Functional Family Protein-glutamate methylesterase/protein-glutamine glutaminase

Enzyme Information

3.1.1.61
Protein-glutamate methylesterase.
based on mapping to UniProt P04042
Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol.
-!- Hydrolyzes the products of EC 2.1.1.77, EC 2.1.1.78, EC 2.1.1.80 and EC 2.1.1.100.
3.5.1.44
Protein-glutamine glutaminase.
based on mapping to UniProt P04042
Protein L-glutamine + H(2)O = protein L-glutamate + NH(3).
-!- Specific for the hydrolysis of the gamma-amide of glutamine substituted at the carboxyl position or both the alpha-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L- glutaminylglycine.

UniProtKB Entries (1)

P04042
CHEB_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Protein-glutamate methylesterase/protein-glutamine glutaminase

PDB Structure

PDB 1A2O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for methylesterase CheB regulation by a phosphorylation-activated domain.
Djordjevic, S., Goudreau, P.N., Xu, Q., Stock, A.M., West, A.H.
Proc.Natl.Acad.Sci.USA