CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1A0H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.
Martin, P.D., Malkowski, M.G., Box, J., Esmon, C.T., Edwards, B.F.
Structure