The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Poly(A) polymerase predicted RNA binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Poly(A) polymerase predicted RNA binding domain

Based on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a template-independent RNA polymerase that specifically incorporates ATP at the 3' end of mRNA. The crystal structure of bovine poly(A) polymerase bound to an ATP analogue at 2.5 A resolution has been determined PMID:10944102. The C-terminal domain unexpectedly folds into a compact domain reminiscent of the RNA-recognition motif fold. The three invariant aspartates of the catalytic triad ligate two of the three active site metals. One of these metals also contacts the adenine ring. Furthermore, conserved, catalytically important residues contact the nucleotide. These contacts, taken together with metal coordination of the adenine base, provide a structural basis for ATP selection by poly(A) polymerase.

PFAM:PF04926,INTERPRO:IPR007010

GO Diversity

Unique GO annotations
34 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
2139 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 81
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 50
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 26
Function
Unique EC: 2
Unique GO: 34
Taxonomy
Unique Species: 2139