The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"PHR domain
".
2.60.120.820
superfamily
This superfamily includes the PHR domain which was first found in Pam, Highwire and RPM-1 proteins, that it is named after. PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterised by the presence of two PHR domains near the N-terminus, which are essential for proper localisation and function. The domain has a beta-sandwich fold composed of 11 anti-parallel beta-strands.
The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
PFAM:PF08005, INTERPRO:IPR012983,DOI:10.1016/j.jmb.2010.02.017
Structures | |
---|---|
Domains: | 5 |
Domain clusters (>95% seq id): | 3 |
Domain clusters (>35% seq id): | 3 |
Unique PDBs: | 3 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 25 |
Function | |
Unique EC: | |
Unique GO: | 79 |
Taxonomy | |
Unique Species: | 463 |