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CATH Superfamily 2.40.50.60

Antifungal protein domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Antifungal protein domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Antifungal protein domain

Antifungal protein consists of five antiparallel beta strands which are highly twisted creating a beta-barrel stabilised by four internal disulphide bridges PMID:7893713. A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site PMID:7893713.

This superfamily entry represents an antifungal protein lysine rich domain, that contributes to the correct folding of the protein, which is necessary for its specific antifungal activity. It has been suggested that this domain might contribute to the cell wall and/or nucleic acids binding activity.

PFAM:PF11402, INTERPRO:IPR022706,DOI:10.1111/j.1742-4658.2009.07011.x

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
75 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 9
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 8
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 3
Taxonomy
Unique Species: 75