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CATH Superfamily 1.20.1250.80

Interleukin-34

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Interleukin-34
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Interleukin-34

Interleukins (IL) are a group of cytokines that modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Structural domains comprising this superfamily share the structure of Interleukin-34 (IL-34), identified as the second functional ligand for colony stimulating factor (CSF)-1R. Upon binding to this receptor, IL-34 promotes differentiation and viability of monocytes and macrophages PMID:18467591.

GO Diversity

Unique GO annotations
13 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
150 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 13
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 13
Taxonomy
Unique Species: 150