Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
Elahmad, Y., Tabart, M., Halley, F., Certal, V., Thompson, F., Filoche-Romme, B., Gruss-Leleu, F., Muller, C., Brollo, M., Fabien, L., Loyau, V., Bertin, L., Richepin, P., Pilorge, F., Desmazeau, P., Girardet, C., Beccari, S., Louboutin, A., Lebourg, G., Le-Roux, J., Terrier, C., Vallee, F., Steier, V., Mathieu, M., Rak, A., Abecassis, P.Y., Vicat, P., Benard, T., Bouaboula, M., Sun, F., Shomali, M., Hebert, A., Levit, M., Cheng, H., Courjaud, A., Ginesty, C., Perrault, C., Garcia-Echeverria, C., McCort, G., Schio, L.
J.Med.Chem.