PDB 6qx2

PDB Information

PDB6QX2
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceStaphylococcus aureus
Primary Citation
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Thalji, R.K., Raha, K., Andreotti, D., Checchia, A., Cui, H., Meneghelli, G., Profeta, R., Tonelli, F., Tommasi, S., Bakshi, T., Donovan, B.T., Howells, A., Jain, S., Nixon, C., Quinque, G., McCloskey, L., Bax, B.D., Neu, M., Chan, P.F., Stavenger, R.A.
Bioorg.Med.Chem.Lett.
HeaderIsomerase
Released2019-03-06
Resolution3.400
CATH Insert Date21 Apr, 2019

PDB Images (49)

PDB Prints

PDB Chains (36)

Chain ID Date inserted into CATH CATH Status
a 21 Apr, 2019 Chopped
A 21 Apr, 2019 Chopped
b 21 Apr, 2019 Holding pen
B 21 Apr, 2019 Holding pen
c 21 Apr, 2019 Chopped
C 21 Apr, 2019 Chopped
d 21 Apr, 2019 Holding pen
D 21 Apr, 2019 Holding pen
e 21 Apr, 2019 Rejected
E 21 Apr, 2019 Rejected
f 21 Apr, 2019 Rejected
F 21 Apr, 2019 Rejected
j 21 Apr, 2019 Chopped
J 21 Apr, 2019 Chopped
k 21 Apr, 2019 Holding pen
K 21 Apr, 2019 Holding pen
l 21 Apr, 2019 Chopped
L 21 Apr, 2019 Chopped
m 21 Apr, 2019 Holding pen
M 21 Apr, 2019 Holding pen
n 21 Apr, 2019 Rejected
N 21 Apr, 2019 Rejected
o 21 Apr, 2019 Rejected
O 21 Apr, 2019 Rejected
r 21 Apr, 2019 Chopped
R 21 Apr, 2019 Chopped
s 21 Apr, 2019 Holding pen
S 21 Apr, 2019 Holding pen
t 21 Apr, 2019 Chopped
T 21 Apr, 2019 Chopped
u 21 Apr, 2019 Holding pen
U 21 Apr, 2019 Holding pen
v 21 Apr, 2019 Rejected
V 21 Apr, 2019 Rejected
w 21 Apr, 2019 Rejected
W 21 Apr, 2019 Rejected

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
6qx2a00 22 Apr, 2019 Holding pen
6qx2A00 22 Apr, 2019 Holding pen
6qx2c00 22 Apr, 2019 Holding pen
6qx2C00 22 Apr, 2019 Holding pen
6qx2j00 22 Apr, 2019 Holding pen
6qx2J00 22 Apr, 2019 Holding pen
6qx2l00 22 Apr, 2019 Holding pen
6qx2L00 22 Apr, 2019 Holding pen
6qx2r00 22 Apr, 2019 Holding pen
6qx2R00 22 Apr, 2019 Holding pen
6qx2t00 22 Apr, 2019 Holding pen
6qx2T00 22 Apr, 2019 Holding pen

UniProtKB Entries (24)

Accession Gene ID Taxon Description
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
P0A0K8 GYRB_STAAU Staphylococcus aureus DNA gyrase subunit B
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