PDB 6qm7

PDB Links
Overview

PDB Information

PDB	6QM7
Method	ELECTRON MICROSCOPY
Host Organism
Gene Source
Primary Citation	Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition. Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C.W., Pena, I., Bingham, R.P., Bueren-Calabuig, J.A., Cantizani, J., Cebrian, D., Craggs, P.D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E.J., Korczynska, J., MacLean, L., Manthri, S., Martinez, M.S., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F.R.C., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R.J., Zuccotto, F., Horn, D., Ferguson, M.A.J., Fairlamb, A.H., Fiandor, J.M., Martin, J., Gray, D.W., Miles, T.J., Gilbert, I.H., Read, K.D., Marco, M., Wyatt, P.G. Proc.Natl.Acad.Sci.USA
Header	Hydrolase
Released	2019-02-01
Resolution	2.800
CATH Insert Date	21 Apr, 2019

PDB Images (50)

6qm7

PDB 6qm7

6qm7a

PDB Chain 6qm7a

6qm7A

PDB Chain 6qm7A

6qm7b

PDB Chain 6qm7b

6qm7B

PDB Chain 6qm7B

6qm7C

PDB Chain 6qm7C

6qm7D

PDB Chain 6qm7D

6qm7E

PDB Chain 6qm7E

6qm7F

PDB Chain 6qm7F

6qm7G

PDB Chain 6qm7G

6qm7H

PDB Chain 6qm7H

6qm7I

PDB Chain 6qm7I

6qm7J

PDB Chain 6qm7J

6qm7K

PDB Chain 6qm7K

6qm7L

PDB Chain 6qm7L

6qm7M

PDB Chain 6qm7M

6qm7N

PDB Chain 6qm7N

6qm7O

PDB Chain 6qm7O

6qm7P

PDB Chain 6qm7P

6qm7Q

PDB Chain 6qm7Q

6qm7R

PDB Chain 6qm7R

6qm7S

PDB Chain 6qm7S

6qm7T

PDB Chain 6qm7T

6qm7U

PDB Chain 6qm7U

6qm7V

PDB Chain 6qm7V

6qm7W

PDB Chain 6qm7W

6qm7X

PDB Chain 6qm7X

6qm7Y

PDB Chain 6qm7Y

6qm7Z

PDB Chain 6qm7Z

6qm7a00

CATH Domain 6qm7a00

6qm7A00

CATH Domain 6qm7A00

6qm7b00

CATH Domain 6qm7b00

6qm7D00

CATH Domain 6qm7D00

6qm7F00

CATH Domain 6qm7F00

6qm7G00

CATH Domain 6qm7G00

6qm7I00

CATH Domain 6qm7I00

6qm7J00

CATH Domain 6qm7J00

6qm7K00

CATH Domain 6qm7K00

6qm7L00

CATH Domain 6qm7L00

6qm7M00

CATH Domain 6qm7M00

6qm7N00

CATH Domain 6qm7N00

6qm7O00

CATH Domain 6qm7O00

6qm7R00

CATH Domain 6qm7R00

6qm7S00

CATH Domain 6qm7S00

6qm7T00

CATH Domain 6qm7T00

6qm7U00

CATH Domain 6qm7U00

6qm7W00

CATH Domain 6qm7W00

6qm7X00

CATH Domain 6qm7X00

6qm7Y00

CATH Domain 6qm7Y00

6qm7Z00

CATH Domain 6qm7Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	21 Apr, 2019	Chopped
A	21 Apr, 2019	Chopped
b	21 Apr, 2019	Chopped
B	21 Apr, 2019	Holding pen
C	21 Apr, 2019	Holding pen
D	21 Apr, 2019	Chopped
E	21 Apr, 2019	Holding pen
F	21 Apr, 2019	Chopped
G	21 Apr, 2019	Chopped
H	21 Apr, 2019	Holding pen
I	21 Apr, 2019	Chopped
J	21 Apr, 2019	Chopped
K	21 Apr, 2019	Chopped
L	21 Apr, 2019	Chopped
M	21 Apr, 2019	Chopped
N	21 Apr, 2019	Chopped
O	21 Apr, 2019	Chopped
P	21 Apr, 2019	Holding pen
Q	21 Apr, 2019	Holding pen
R	21 Apr, 2019	Chopped
S	21 Apr, 2019	Chopped
T	21 Apr, 2019	Chopped
U	21 Apr, 2019	Chopped
V	21 Apr, 2019	Holding pen
W	21 Apr, 2019	Chopped
X	21 Apr, 2019	Chopped
Y	21 Apr, 2019	Chopped
Z	21 Apr, 2019	Chopped

CATH Domains (21)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6qm7a00	22 Apr, 2019	3.60.20.10	Assigned
6qm7A00	22 Apr, 2019	3.60.20.10	Assigned
6qm7b00	22 Apr, 2019	3.60.20.10	Assigned
6qm7D00	22 Apr, 2019	3.60.20.10	Assigned
6qm7F00	22 Apr, 2019	3.60.20.10	Assigned
6qm7G00	22 Apr, 2019	3.60.20.10	Assigned
6qm7I00	22 Apr, 2019	3.60.20.10	Assigned
6qm7J00	22 Apr, 2019	3.60.20.10	Assigned
6qm7K00	22 Apr, 2019	3.60.20.10	Assigned
6qm7L00	22 Apr, 2019	3.60.20.10	Assigned
6qm7M00	22 Apr, 2019	3.60.20.10	Assigned
6qm7N00	22 Apr, 2019	3.60.20.10	Assigned
6qm7O00	22 Apr, 2019	3.60.20.10	Assigned
6qm7R00	22 Apr, 2019	3.60.20.10	Assigned
6qm7S00	22 Apr, 2019	3.60.20.10	Assigned
6qm7T00	22 Apr, 2019	3.60.20.10	Assigned
6qm7U00	22 Apr, 2019	3.60.20.10	Assigned
6qm7W00	22 Apr, 2019	3.60.20.10	Assigned
6qm7X00	22 Apr, 2019	3.60.20.10	Assigned
6qm7Y00	22 Apr, 2019	3.60.20.10	Assigned
6qm7Z00	22 Apr, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
A4HV47	A4HV47_LEIIN	Leishmania infantum	Proteasome subunit beta
Q9GNZ8	Q9GNZ8_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4IDD6	A4IDD6_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HN55	A4HN55_LEIBR	Leishmania braziliensis	Proteasome subunit beta
A4I357	A4I357_LEIIN	Leishmania infantum	Proteasome endopeptidase complex
A4I384	A4I384_LEIIN	Leishmania infantum	Proteasome subunit beta
Q7JMX2	Q7JMX2_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4IDD6	A4IDD6_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HVX3	A4HVX3_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HV47	A4HV47_LEIIN	Leishmania infantum	Proteasome subunit beta
A0A381MU64	A0A381MU64_LEIIN	Leishmania infantum	Proteasome subunit beta
A0A381MU64	A0A381MU64_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HZI9	A4HZI9_LEIIN	Leishmania infantum	Proteasome subunit alpha type
Q7JMX2	Q7JMX2_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HUT6	A4HUT6_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4IDD0	A4IDD0_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HN55	A4HN55_LEIBR	Leishmania braziliensis	Proteasome subunit beta
Q9GNZ8	Q9GNZ8_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HZI9	A4HZI9_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4IDD0	A4IDD0_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4I384	A4I384_LEIIN	Leishmania infantum	Proteasome subunit beta
A4I357	A4I357_LEIIN	Leishmania infantum	Proteasome endopeptidase complex
A4ICV5	A4ICV5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4ICV5	A4ICV5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HUT6	A4HUT6_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HVX3	A4HVX3_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HSQ5	A4HSQ5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HSQ5	A4HSQ5_LEIIN	Leishmania infantum	Proteasome subunit beta