PDB 6o98

PDB Information

PDB6O98
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR gamma t Inverse Agonists.
Duan, J.J., Lu, Z., Jiang, B., Stachura, S., Weigelt, C.A., Sack, J.S., Khan, J., Ruzanov, M., Galella, M.A., Wu, D.R., Yarde, M., Shen, D.R., Shuster, D.J., Borowski, V., Xie, J.H., Zhang, L., Vanteru, S., Gupta, A.K., Mathur, A., Zhao, Q., Foster, W., Salter-Cid, L.M., Carter, P.H., Dhar, T.G.M.
ACS Med Chem Lett
HeaderTranscription/Inhibitor
Released2019-03-13
Resolution2.290
CATH Insert Date24 Mar, 2019

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 24 Mar, 2019 Chopped
B 24 Mar, 2019 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6o98A00 25 Mar, 2019 1.10.565.10 Assigned
6o98B00 25 Mar, 2019 1.10.565.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma