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PDB 6ne5

PDB Information

PDB6NE5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli K-12
Gene SourceHomo sapiens
Primary Citation
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
Lee, T., Christov, P.P., Shaw, S., Tarr, J.C., Zhao, B., Veerasamy, N., Jeon, K.O., Mills, J.J., Bian, Z., Sensintaffar, J.L., Arnold, A.L., Fogarty, S.A., Perry, E., Ramsey, H.E., Cook, R.S., Hollingshead, M., Davis Millin, M., Lee, K.M., Koss, B., Budhraja, A., Opferman, J.T., Kim, K., Arteaga, C.L., Moore, W.J., Olejniczak, E.T., Savona, M.R., Fesik, S.W.
J.Med.Chem.
HeaderApoptosis
Released2018-12-17
Resolution1.850
CATH Insert Date21 Apr, 2019

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 21 Apr, 2019 Chopped
B 21 Apr, 2019 Chopped
C 21 Apr, 2019 Chopped
D 21 Apr, 2019 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6ne5A01 22 Apr, 2019 1.10.437.10 Assigned
6ne5B01 22 Apr, 2019 1.10.437.10 Assigned
6ne5C01 22 Apr, 2019 1.10.437.10 Assigned
6ne5D01 22 Apr, 2019 1.10.437.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
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