PDB Information

PDB6NAO
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Hall, J., Brault, A., Vincent, F., Weng, S., Wang, H., Dumlao, D., Aulabaugh, A., Aivazian, D., Castro, D., Chen, M., Culp, J., Dower, K., Gardner, J., Hawrylik, S., Golenbock, D., Hepworth, D., Horn, M., Jones, L., Jones, P., Latz, E., Li, J., Lin, L.L., Lin, W., Lin, D., Lovering, F., Niljanskul, N., Nistler, R., Pierce, B., Plotnikova, O., Schmitt, D., Shanker, S., Smith, J., Snyder, W., Subashi, T., Trujillo, J., Tyminski, E., Wang, G., Wong, J., Lefker, B., Dakin, L., Leach, K.
PLoS ONE
HeaderTransferase/Transferase Inhibitor
Released2018-12-06
Resolution3.230
CATH Insert Date23 Dec, 2018

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 23 Dec, 2018 Chopped
B 23 Dec, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6naoA01 27 Dec, 2018 1.10.1410.40 Assigned
6naoA02 27 Dec, 2018 3.30.460.90 Assigned
6naoB01 27 Dec, 2018 1.10.1410.40 Assigned
6naoB02 27 Dec, 2018 3.30.460.90 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q8N884 CGAS_HUMAN Homo sapiens Cyclic GMP-AMP synthase
Q8N884 CGAS_HUMAN Homo sapiens Cyclic GMP-AMP synthase