Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
Fell, J.B., Fischer, J.P., Baer, B.R., Ballard, J., Blake, J.F., Bouhana, K., Brandhuber, B.J., Briere, D.M., Burgess, L.E., Burkard, M.R., Chiang, H., Chicarelli, M.J., Davidson, K., Gaudino, J.J., Hallin, J., Hanson, L., Hee, K., Hicken, E.J., Hinklin, R.J., Marx, M.A., Mejia, M.J., Olson, P., Savechenkov, P., Sudhakar, N., Tang, T.P., Vigers, G.P., Zecca, H., Christensen, J.G.
ACS Med Chem Lett