PDB Information

PDB6N0P
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
Ramurthy, S., Taft, B.R., Aversa, R.J., Barsanti, P.A., Burger, M.T., Lou, Y., Nishiguchi, G.A., Rico, A., Setti, L., Smith, A., Subramanian, S., Tamez, V., Tanner, H., Wan, L., Hu, C., Appleton, B.A., Mamo, M., Tandeske, L., Tellew, J.E., Huang, S., Yue, Q., Chaudhary, A., Tian, H., Iyer, R., Hassan, A.Q., Mathews Griner, L.A., La Bonte, L.R., Cooke, V.G., Van Abbema, A., Merritt, H., Gampa, K., Feng, F., Yuan, J., Mishina, Y., Wang, Y., Haling, J.R., Vaziri, S., Hekmat-Nejad, M., Polyakov, V., Zang, R., Sethuraman, V., Amiri, P., Singh, M., Sellers, W.R., Lees, E., Shao, W., Dillon, M.P., Stuart, D.D.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2018-11-07
Resolution2.370
CATH Insert Date15 Sep, 2019

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Chain ID Date inserted into CATH CATH Status

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Domain ID Date inserted into CATH Superfamily CATH Status

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Accession Gene ID Taxon Description