Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
Huang, W.S., Liu, S., Zou, D., Thomas, M., Wang, Y., Zhou, T., Romero, J., Kohlmann, A., Li, F., Qi, J., Cai, L., Dwight, T.A., Xu, Y., Xu, R., Dodd, R., Toms, A., Parillon, L., Lu, X., Anjum, R., Zhang, S., Wang, F., Keats, J., Wardwell, S.D., Ning, Y., Xu, Q., Moran, L.E., Mohemmad, Q.K., Jang, H.G., Clackson, T., Narasimhan, N.I., Rivera, V.M., Zhu, X., Dalgarno, D., Shakespeare, W.C.
J. Med. Chem.