PDB 6mo9

PDB Information

PDB6MO9
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Sperandio, D., Aktoudianakis, V., Babaoglu, K., Chen, X., Elbel, K., Chin, G., Corkey, B., Du, J., Jiang, B., Kobayashi, T., Mackman, R., Martinez, R., Yang, H., Zablocki, J., Kusam, S., Jordan, K., Webb, H., Bates, J.G., Lad, L., Mish, M., Niedziela-Majka, A., Metobo, S., Sapre, A., Hung, M., Jin, D., Fung, W., Kan, E., Eisenberg, G., Larson, N., Newby, Z.E.R., Lansdon, E., Tay, C., Neve, R.M., Shevick, S.L., Breckenridge, D.G.
Bioorg. Med. Chem.
HeaderTranscription/Transcription Inhibitor
Released2018-10-04
Resolution1.800
CATH Insert Date27 Jan, 2019

PDB Images (7)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 27 Jan, 2019 Chopped
B 27 Jan, 2019 Chopped
C 27 Jan, 2019 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
6mo9A00 28 Jan, 2019 1.20.920.10 Assigned
6mo9B00 28 Jan, 2019 1.20.920.10 Assigned
6mo9C00 28 Jan, 2019 1.20.920.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2