PDB 6mdb

PDB Links
Overview

PDB Information

PDB	6MDB
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. Sarver, P., Acker, M., Bagdanoff, J.T., Chen, Z., Chen, Y.N., Chan, H., Firestone, B., Fodor, M., Fortanet, J., Hao, H., Hentemann, M., Kato, M., Koenig, R., LaBonte, L.R., Liu, G., Liu, S., Liu, C., McNeill, E., Mohseni, M., Sendzik, M., Stams, T., Spence, S., Tamez, V., Tichkule, R., Towler, C., Wang, H., Wang, P., Williams, S.L., Yu, B., LaMarche, M.J. J. Med. Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2018-09-04
Resolution	2.340
CATH Insert Date	17 Feb, 2019

PDB Images (9)

Image of CATH 6mdb

6mdb

PDB 6mdb

Image of CATH 6mdbA

6mdbA

PDB Chain 6mdbA

Image of CATH 6mdbB

6mdbB

PDB Chain 6mdbB

Image of CATH 6mdbA01

6mdbA01

CATH Domain 6mdbA01

Image of CATH 6mdbA02

6mdbA02

CATH Domain 6mdbA02

Image of CATH 6mdbA03

6mdbA03

CATH Domain 6mdbA03

Image of CATH 6mdbB01

6mdbB01

CATH Domain 6mdbB01

Image of CATH 6mdbB02

6mdbB02

CATH Domain 6mdbB02

Image of CATH 6mdbB03

6mdbB03

CATH Domain 6mdbB03

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	17 Feb, 2019	Chopped
B	17 Feb, 2019	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6mdbA01	18 Feb, 2019	3.30.505.10	Assigned
6mdbA02	18 Feb, 2019	3.30.505.10	Assigned
6mdbA03	18 Feb, 2019	3.90.190.10	Assigned
6mdbB01	18 Feb, 2019	3.30.505.10	Assigned
6mdbB02	18 Feb, 2019	3.30.505.10	Assigned
6mdbB03	18 Feb, 2019	3.90.190.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q06124	PTN11_HUMAN	Homo sapiens	Tyrosine-protein phosphatase non-receptor type 11
Q06124	PTN11_HUMAN	Homo sapiens	Tyrosine-protein phosphatase non-receptor type 11