PDB 6md7

PDB Information

PDB6MD7
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Sarver, P., Acker, M., Bagdanoff, J.T., Chen, Z., Chen, Y.N., Chan, H., Firestone, B., Fodor, M., Fortanet, J., Hao, H., Hentemann, M., Kato, M., Koenig, R., LaBonte, L.R., Liu, G., Liu, S., Liu, C., McNeill, E., Mohseni, M., Sendzik, M., Stams, T., Spence, S., Tamez, V., Tichkule, R., Towler, C., Wang, H., Wang, P., Williams, S.L., Yu, B., LaMarche, M.J.
J. Med. Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2018-09-04
Resolution1.960
CATH Insert Date17 Feb, 2019

PDB Images (9)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 17 Feb, 2019 Chopped
B 17 Feb, 2019 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
6md7A01 18 Feb, 2019 3.30.505.10 Assigned
6md7A02 18 Feb, 2019 3.30.505.10 Assigned
6md7A03 18 Feb, 2019 3.90.190.10 Assigned
6md7B01 18 Feb, 2019 3.30.505.10 Assigned
6md7B02 18 Feb, 2019 3.30.505.10 Assigned
6md7B03 18 Feb, 2019 3.90.190.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11