PDB Information

PDB6HWB
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S.
J.Med.Chem.
HeaderHydrolase
Released2018-10-11
Resolution2.600
CATH Insert Date03 Feb, 2019

PDB Images (57)

PDB Prints

PDB Chains (28)

Chain ID Date inserted into CATH CATH Status
a 03 Feb, 2019 Chopped
A 03 Feb, 2019 Chopped
b 03 Feb, 2019 Chopped
B 03 Feb, 2019 Chopped
C 03 Feb, 2019 Chopped
D 03 Feb, 2019 Chopped
E 03 Feb, 2019 Chopped
F 03 Feb, 2019 Chopped
G 03 Feb, 2019 Chopped
H 03 Feb, 2019 Chopped
I 03 Feb, 2019 Chopped
J 03 Feb, 2019 Chopped
K 03 Feb, 2019 Chopped
L 03 Feb, 2019 Chopped
M 03 Feb, 2019 Chopped
N 03 Feb, 2019 Chopped
O 03 Feb, 2019 Chopped
P 03 Feb, 2019 Chopped
Q 03 Feb, 2019 Chopped
R 03 Feb, 2019 Chopped
S 03 Feb, 2019 Chopped
T 03 Feb, 2019 Chopped
U 03 Feb, 2019 Chopped
V 03 Feb, 2019 Chopped
W 03 Feb, 2019 Chopped
X 03 Feb, 2019 Chopped
Y 03 Feb, 2019 Chopped
Z 03 Feb, 2019 Chopped

CATH Domains (28)

Domain ID Date inserted into CATH Superfamily CATH Status
6hwba00 04 Feb, 2019 3.60.20.10 Assigned
6hwbA00 04 Feb, 2019 3.60.20.10 Assigned
6hwbb00 04 Feb, 2019 3.60.20.10 Assigned
6hwbB00 04 Feb, 2019 3.60.20.10 Assigned
6hwbC00 04 Feb, 2019 3.60.20.10 Assigned
6hwbD00 04 Feb, 2019 3.60.20.10 Assigned
6hwbE00 04 Feb, 2019 3.60.20.10 Assigned
6hwbF00 04 Feb, 2019 3.60.20.10 Assigned
6hwbG00 04 Feb, 2019 3.60.20.10 Assigned
6hwbH00 04 Feb, 2019 3.60.20.10 Assigned
6hwbI00 04 Feb, 2019 3.60.20.10 Assigned
6hwbJ00 04 Feb, 2019 3.60.20.10 Assigned
6hwbK00 04 Feb, 2019 3.60.20.10 Assigned
6hwbL00 04 Feb, 2019 3.60.20.10 Assigned
6hwbM00 04 Feb, 2019 3.60.20.10 Assigned
6hwbN00 04 Feb, 2019 3.60.20.10 Assigned
6hwbO00 04 Feb, 2019 3.60.20.10 Assigned
6hwbP00 04 Feb, 2019 3.60.20.10 Assigned
6hwbQ00 04 Feb, 2019 3.60.20.10 Assigned
6hwbR00 04 Feb, 2019 3.60.20.10 Assigned
6hwbS00 04 Feb, 2019 3.60.20.10 Assigned
6hwbT00 04 Feb, 2019 3.60.20.10 Assigned
6hwbU00 04 Feb, 2019 3.60.20.10 Assigned
6hwbV00 04 Feb, 2019 3.60.20.10 Assigned
6hwbW00 04 Feb, 2019 3.60.20.10 Assigned
6hwbX00 04 Feb, 2019 3.60.20.10 Assigned
6hwbY00 04 Feb, 2019 3.60.20.10 Assigned
6hwbZ00 04 Feb, 2019 3.60.20.10 Assigned

UniProtKB Entries (28)

Accession Gene ID Taxon Description
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P25043 PSB2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-2
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P25043 PSB2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-2
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7