PDB 6hw8

PDB Links
Overview

PDB Information

PDB	6HW8
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw8

PDB 6hw8

6hw8a

PDB Chain 6hw8a

6hw8A

PDB Chain 6hw8A

6hw8b

PDB Chain 6hw8b

6hw8B

PDB Chain 6hw8B

6hw8C

PDB Chain 6hw8C

6hw8D

PDB Chain 6hw8D

6hw8E

PDB Chain 6hw8E

6hw8F

PDB Chain 6hw8F

6hw8G

PDB Chain 6hw8G

6hw8H

PDB Chain 6hw8H

6hw8I

PDB Chain 6hw8I

6hw8J

PDB Chain 6hw8J

6hw8K

PDB Chain 6hw8K

6hw8L

PDB Chain 6hw8L

6hw8M

PDB Chain 6hw8M

6hw8N

PDB Chain 6hw8N

6hw8O

PDB Chain 6hw8O

6hw8P

PDB Chain 6hw8P

6hw8Q

PDB Chain 6hw8Q

6hw8R

PDB Chain 6hw8R

6hw8S

PDB Chain 6hw8S

6hw8T

PDB Chain 6hw8T

6hw8U

PDB Chain 6hw8U

6hw8V

PDB Chain 6hw8V

6hw8W

PDB Chain 6hw8W

6hw8X

PDB Chain 6hw8X

6hw8Y

PDB Chain 6hw8Y

6hw8Z

PDB Chain 6hw8Z

6hw8a00

CATH Domain 6hw8a00

6hw8A00

CATH Domain 6hw8A00

6hw8b00

CATH Domain 6hw8b00

6hw8B00

CATH Domain 6hw8B00

6hw8C00

CATH Domain 6hw8C00

6hw8D00

CATH Domain 6hw8D00

6hw8E00

CATH Domain 6hw8E00

6hw8F00

CATH Domain 6hw8F00

6hw8G00

CATH Domain 6hw8G00

6hw8H00

CATH Domain 6hw8H00

6hw8I00

CATH Domain 6hw8I00

6hw8J00

CATH Domain 6hw8J00

6hw8K00

CATH Domain 6hw8K00

6hw8L00

CATH Domain 6hw8L00

6hw8M00

CATH Domain 6hw8M00

6hw8N00

CATH Domain 6hw8N00

6hw8O00

CATH Domain 6hw8O00

6hw8P00

CATH Domain 6hw8P00

6hw8Q00

CATH Domain 6hw8Q00

6hw8R00

CATH Domain 6hw8R00

6hw8S00

CATH Domain 6hw8S00

6hw8T00

CATH Domain 6hw8T00

6hw8U00

CATH Domain 6hw8U00

6hw8V00

CATH Domain 6hw8V00

6hw8W00

CATH Domain 6hw8W00

6hw8X00

CATH Domain 6hw8X00

6hw8Y00

CATH Domain 6hw8Y00

6hw8Z00

CATH Domain 6hw8Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw8a00	04 Feb, 2019	3.60.20.10	Assigned
6hw8A00	04 Feb, 2019	3.60.20.10	Assigned
6hw8b00	04 Feb, 2019	3.60.20.10	Assigned
6hw8B00	04 Feb, 2019	3.60.20.10	Assigned
6hw8C00	04 Feb, 2019	3.60.20.10	Assigned
6hw8D00	04 Feb, 2019	3.60.20.10	Assigned
6hw8E00	04 Feb, 2019	3.60.20.10	Assigned
6hw8F00	04 Feb, 2019	3.60.20.10	Assigned
6hw8G00	04 Feb, 2019	3.60.20.10	Assigned
6hw8H00	04 Feb, 2019	3.60.20.10	Assigned
6hw8I00	04 Feb, 2019	3.60.20.10	Assigned
6hw8J00	04 Feb, 2019	3.60.20.10	Assigned
6hw8K00	04 Feb, 2019	3.60.20.10	Assigned
6hw8L00	04 Feb, 2019	3.60.20.10	Assigned
6hw8M00	04 Feb, 2019	3.60.20.10	Assigned
6hw8N00	04 Feb, 2019	3.60.20.10	Assigned
6hw8O00	04 Feb, 2019	3.60.20.10	Assigned
6hw8P00	04 Feb, 2019	3.60.20.10	Assigned
6hw8Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw8R00	04 Feb, 2019	3.60.20.10	Assigned
6hw8S00	04 Feb, 2019	3.60.20.10	Assigned
6hw8T00	04 Feb, 2019	3.60.20.10	Assigned
6hw8U00	04 Feb, 2019	3.60.20.10	Assigned
6hw8V00	04 Feb, 2019	3.60.20.10	Assigned
6hw8W00	04 Feb, 2019	3.60.20.10	Assigned
6hw8X00	04 Feb, 2019	3.60.20.10	Assigned
6hw8Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw8Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1