PDB 6hvx

PDB Links
Overview

PDB Information

PDB	6HVX
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvx

PDB 6hvx

6hvxa

PDB Chain 6hvxa

6hvxA

PDB Chain 6hvxA

6hvxb

PDB Chain 6hvxb

6hvxB

PDB Chain 6hvxB

6hvxC

PDB Chain 6hvxC

6hvxD

PDB Chain 6hvxD

6hvxE

PDB Chain 6hvxE

6hvxF

PDB Chain 6hvxF

6hvxG

PDB Chain 6hvxG

6hvxH

PDB Chain 6hvxH

6hvxI

PDB Chain 6hvxI

6hvxJ

PDB Chain 6hvxJ

6hvxK

PDB Chain 6hvxK

6hvxL

PDB Chain 6hvxL

6hvxM

PDB Chain 6hvxM

6hvxN

PDB Chain 6hvxN

6hvxO

PDB Chain 6hvxO

6hvxP

PDB Chain 6hvxP

6hvxQ

PDB Chain 6hvxQ

6hvxR

PDB Chain 6hvxR

6hvxS

PDB Chain 6hvxS

6hvxT

PDB Chain 6hvxT

6hvxU

PDB Chain 6hvxU

6hvxV

PDB Chain 6hvxV

6hvxW

PDB Chain 6hvxW

6hvxX

PDB Chain 6hvxX

6hvxY

PDB Chain 6hvxY

6hvxZ

PDB Chain 6hvxZ

6hvxa00

CATH Domain 6hvxa00

6hvxA00

CATH Domain 6hvxA00

6hvxb00

CATH Domain 6hvxb00

6hvxB00

CATH Domain 6hvxB00

6hvxC00

CATH Domain 6hvxC00

6hvxD00

CATH Domain 6hvxD00

6hvxE00

CATH Domain 6hvxE00

6hvxF00

CATH Domain 6hvxF00

6hvxG00

CATH Domain 6hvxG00

6hvxH00

CATH Domain 6hvxH00

6hvxI00

CATH Domain 6hvxI00

6hvxJ00

CATH Domain 6hvxJ00

6hvxK00

CATH Domain 6hvxK00

6hvxL00

CATH Domain 6hvxL00

6hvxM00

CATH Domain 6hvxM00

6hvxN00

CATH Domain 6hvxN00

6hvxO00

CATH Domain 6hvxO00

6hvxP00

CATH Domain 6hvxP00

6hvxQ00

CATH Domain 6hvxQ00

6hvxR00

CATH Domain 6hvxR00

6hvxS00

CATH Domain 6hvxS00

6hvxT00

CATH Domain 6hvxT00

6hvxU00

CATH Domain 6hvxU00

6hvxV00

CATH Domain 6hvxV00

6hvxW00

CATH Domain 6hvxW00

6hvxX00

CATH Domain 6hvxX00

6hvxY00

CATH Domain 6hvxY00

6hvxZ00

CATH Domain 6hvxZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvxa00	04 Feb, 2019	3.60.20.10	Assigned
6hvxA00	04 Feb, 2019	3.60.20.10	Assigned
6hvxb00	04 Feb, 2019	3.60.20.10	Assigned
6hvxB00	04 Feb, 2019	3.60.20.10	Assigned
6hvxC00	04 Feb, 2019	3.60.20.10	Assigned
6hvxD00	04 Feb, 2019	3.60.20.10	Assigned
6hvxE00	04 Feb, 2019	3.60.20.10	Assigned
6hvxF00	04 Feb, 2019	3.60.20.10	Assigned
6hvxG00	04 Feb, 2019	3.60.20.10	Assigned
6hvxH00	04 Feb, 2019	3.60.20.10	Assigned
6hvxI00	04 Feb, 2019	3.60.20.10	Assigned
6hvxJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvxK00	04 Feb, 2019	3.60.20.10	Assigned
6hvxL00	04 Feb, 2019	3.60.20.10	Assigned
6hvxM00	04 Feb, 2019	3.60.20.10	Assigned
6hvxN00	04 Feb, 2019	3.60.20.10	Assigned
6hvxO00	04 Feb, 2019	3.60.20.10	Assigned
6hvxP00	04 Feb, 2019	3.60.20.10	Assigned
6hvxQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvxR00	04 Feb, 2019	3.60.20.10	Assigned
6hvxS00	04 Feb, 2019	3.60.20.10	Assigned
6hvxT00	04 Feb, 2019	3.60.20.10	Assigned
6hvxU00	04 Feb, 2019	3.60.20.10	Assigned
6hvxV00	04 Feb, 2019	3.60.20.10	Assigned
6hvxW00	04 Feb, 2019	3.60.20.10	Assigned
6hvxX00	04 Feb, 2019	3.60.20.10	Assigned
6hvxY00	04 Feb, 2019	3.60.20.10	Assigned
6hvxZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5