A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
Johnson, C.N., Ahn, J.S., Buck, I.M., Chiarparin, E., Day, J.E.H., Hopkins, A., Howard, S., Lewis, E.J., Martins, V., Millemaggi, A., Munck, J.M., Page, L.W., Peakman, T., Reader, M., Rich, S.J., Saxty, G., Smyth, T., Thompson, N.T., Ward, G.A., Williams, P.A., Wilsher, N.E., Chessari, G.
J. Med. Chem.