PDB 6h39

PDB Links
Overview

PDB Information

PDB	6H39
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. Bhatia, S., Krieger, V., Groll, M., Osko, J.D., Reßing, N., Ahlert, H., Borkhardt, A., Kurz, T., Christianson, D.W., Hauer, J., Hansen, F.K. J. Med. Chem.
Header	Hydrolase
Released	2018-07-17
Resolution	2.500
CATH Insert Date	16 Dec, 2018

PDB Images (57)

6h39

PDB 6h39

6h39a

PDB Chain 6h39a

6h39A

PDB Chain 6h39A

6h39b

PDB Chain 6h39b

6h39B

PDB Chain 6h39B

6h39C

PDB Chain 6h39C

6h39D

PDB Chain 6h39D

6h39E

PDB Chain 6h39E

6h39F

PDB Chain 6h39F

6h39G

PDB Chain 6h39G

6h39H

PDB Chain 6h39H

6h39I

PDB Chain 6h39I

6h39J

PDB Chain 6h39J

6h39K

PDB Chain 6h39K

6h39L

PDB Chain 6h39L

6h39M

PDB Chain 6h39M

6h39N

PDB Chain 6h39N

6h39O

PDB Chain 6h39O

6h39P

PDB Chain 6h39P

6h39Q

PDB Chain 6h39Q

6h39R

PDB Chain 6h39R

6h39S

PDB Chain 6h39S

6h39T

PDB Chain 6h39T

6h39U

PDB Chain 6h39U

6h39V

PDB Chain 6h39V

6h39W

PDB Chain 6h39W

6h39X

PDB Chain 6h39X

6h39Y

PDB Chain 6h39Y

6h39Z

PDB Chain 6h39Z

6h39a00

CATH Domain 6h39a00

6h39A00

CATH Domain 6h39A00

6h39b00

CATH Domain 6h39b00

6h39B00

CATH Domain 6h39B00

6h39C00

CATH Domain 6h39C00

6h39D00

CATH Domain 6h39D00

6h39E00

CATH Domain 6h39E00

6h39F00

CATH Domain 6h39F00

6h39G00

CATH Domain 6h39G00

6h39H00

CATH Domain 6h39H00

6h39I00

CATH Domain 6h39I00

6h39J00

CATH Domain 6h39J00

6h39K00

CATH Domain 6h39K00

6h39L00

CATH Domain 6h39L00

6h39M00

CATH Domain 6h39M00

6h39N00

CATH Domain 6h39N00

6h39O00

CATH Domain 6h39O00

6h39P00

CATH Domain 6h39P00

6h39Q00

CATH Domain 6h39Q00

6h39R00

CATH Domain 6h39R00

6h39S00

CATH Domain 6h39S00

6h39T00

CATH Domain 6h39T00

6h39U00

CATH Domain 6h39U00

6h39V00

CATH Domain 6h39V00

6h39W00

CATH Domain 6h39W00

6h39X00

CATH Domain 6h39X00

6h39Y00

CATH Domain 6h39Y00

6h39Z00

CATH Domain 6h39Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	16 Dec, 2018	Chopped
A	16 Dec, 2018	Chopped
b	16 Dec, 2018	Chopped
B	16 Dec, 2018	Chopped
C	16 Dec, 2018	Chopped
D	16 Dec, 2018	Chopped
E	16 Dec, 2018	Chopped
F	16 Dec, 2018	Chopped
G	16 Dec, 2018	Chopped
H	16 Dec, 2018	Chopped
I	16 Dec, 2018	Chopped
J	16 Dec, 2018	Chopped
K	16 Dec, 2018	Chopped
L	16 Dec, 2018	Chopped
M	16 Dec, 2018	Chopped
N	16 Dec, 2018	Chopped
O	16 Dec, 2018	Chopped
P	16 Dec, 2018	Chopped
Q	16 Dec, 2018	Chopped
R	16 Dec, 2018	Chopped
S	16 Dec, 2018	Chopped
T	16 Dec, 2018	Chopped
U	16 Dec, 2018	Chopped
V	16 Dec, 2018	Chopped
W	16 Dec, 2018	Chopped
X	16 Dec, 2018	Chopped
Y	16 Dec, 2018	Chopped
Z	16 Dec, 2018	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6h39a00	28 Feb, 2019	3.60.20.10	Assigned
6h39A00	28 Feb, 2019	3.60.20.10	Assigned
6h39b00	28 Feb, 2019	3.60.20.10	Assigned
6h39B00	28 Feb, 2019	3.60.20.10	Assigned
6h39C00	28 Feb, 2019	3.60.20.10	Assigned
6h39D00	28 Feb, 2019	3.60.20.10	Assigned
6h39E00	28 Feb, 2019	3.60.20.10	Assigned
6h39F00	28 Feb, 2019	3.60.20.10	Assigned
6h39G00	28 Feb, 2019	3.60.20.10	Assigned
6h39H00	28 Feb, 2019	3.60.20.10	Assigned
6h39I00	28 Feb, 2019	3.60.20.10	Assigned
6h39J00	28 Feb, 2019	3.60.20.10	Assigned
6h39K00	28 Feb, 2019	3.60.20.10	Assigned
6h39L00	28 Feb, 2019	3.60.20.10	Assigned
6h39M00	28 Feb, 2019	3.60.20.10	Assigned
6h39N00	28 Feb, 2019	3.60.20.10	Assigned
6h39O00	28 Feb, 2019	3.60.20.10	Assigned
6h39P00	28 Feb, 2019	3.60.20.10	Assigned
6h39Q00	28 Feb, 2019	3.60.20.10	Assigned
6h39R00	28 Feb, 2019	3.60.20.10	Assigned
6h39S00	28 Feb, 2019	3.60.20.10	Assigned
6h39T00	28 Feb, 2019	3.60.20.10	Assigned
6h39U00	28 Feb, 2019	3.60.20.10	Assigned
6h39V00	28 Feb, 2019	3.60.20.10	Assigned
6h39W00	28 Feb, 2019	3.60.20.10	Assigned
6h39X00	28 Feb, 2019	3.60.20.10	Assigned
6h39Y00	28 Feb, 2019	3.60.20.10	Assigned
6h39Z00	28 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5