PDB Information

PDB6G5K
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceClostridium botulinum
Primary Citation
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott, M., Favre-Guilmard, C., Liu, S.M., Maignel, J., Masuyer, G., Beard, M., Boone, C., Carre, D., Kalinichev, M., Lezmi, S., Mir, I., Nicoleau, C., Palan, S., Perier, C., Raban, E., Zhang, S., Dong, M., Stenmark, P., Krupp, J.
Sci Adv
HeaderToxin
Released2018-03-29
Resolution2.000
CATH Insert Date20 Jan, 2019

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 20 Jan, 2019 Chopped
B 20 Jan, 2019 Chopped
C 20 Jan, 2019 Rejected
D 20 Jan, 2019 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6g5kA01 21 Jan, 2019 2.60.120.200 Assigned
6g5kA02 21 Jan, 2019 2.80.10.50 Assigned
6g5kB01 21 Jan, 2019 2.60.120.200 Assigned
6g5kB02 21 Jan, 2019 2.80.10.50 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P10844 BXB_CLOBO Clostridium botulinum Botulinum neurotoxin type B
P10844 BXB_CLOBO Clostridium botulinum Botulinum neurotoxin type B
P21579 SYT1_HUMAN Homo sapiens Synaptotagmin-1
P21579 SYT1_HUMAN Homo sapiens Synaptotagmin-1