Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
Qin, C., Hu, Y., Zhou, B., Fernandez-Salas, E., Yang, C.Y., Liu, L., McEachern, D., Przybranowski, S., Wang, M., Stuckey, J., Meagher, J., Bai, L., Chen, Z., Lin, M., Yang, J., Ziazadeh, D.N., Xu, F., Hu, J., Xiang, W., Huang, L., Li, S., Wen, B., Sun, D., Wang, S.
J. Med. Chem.