PDB 6d5w

PDB Information

PDB6D5W
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W.
J. Med. Chem.
HeaderSignaling Protein
Released2018-04-19
Resolution2.480
CATH Insert Date31 Mar, 2019

PDB Images (8)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
Q 31 Mar, 2019 Chopped
R 31 Mar, 2019 Chopped
S 31 Mar, 2019 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6d5wQ00 01 Apr, 2019 3.40.50.300 Assigned
6d5wR00 01 Apr, 2019 3.40.50.300 Assigned
6d5wS01 01 Apr, 2019 1.20.870.10 Assigned
6d5wS02 01 Apr, 2019 1.10.840.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q07889 SOS1_HUMAN Homo sapiens Son of sevenless homolog 1
P01112 RASH_HUMAN Homo sapiens GTPase HRas
P01112 RASH_HUMAN Homo sapiens GTPase HRas