PDB Information

PDB6CUP
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
Abbott, J.R., Patel, P.A., Howes, J.E., Akan, D.T., Kennedy, J.P., Burns, M.C., Browning, C.F., Sun, Q., Rossanese, O.W., Phan, J., Waterson, A.G., Fesik, S.W.
ACS Med Chem Lett
HeaderSignaling Protein
Released2018-03-26
Resolution1.830
CATH Insert Date10 Feb, 2019

PDB Images (8)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 10 Feb, 2019 Chopped
B 10 Feb, 2019 Chopped
C 10 Feb, 2019 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6cupA00 11 Feb, 2019 3.40.50.300 Assigned
6cupB01 11 Feb, 2019 1.20.870.10 Assigned
6cupB02 11 Feb, 2019 1.10.840.10 Assigned
6cupC00 11 Feb, 2019 3.40.50.300 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P01112 RASH_HUMAN Homo sapiens GTPase HRas
P01112 RASH_HUMAN Homo sapiens GTPase HRas
Q07889 SOS1_HUMAN Homo sapiens Son of sevenless homolog 1