PDB Information

PDB6CN6
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Schnute, M.E., Wennerstal, M., Alley, J., Bengtsson, M., Blinn, J.R., Bolten, C.W., Braden, T., Bonn, T., Carlsson, B., Caspers, N., Chen, M., Choi, C., Collis, L.P., Crouse, K., Farnegardh, M., Fennell, K.F., Fish, S., Flick, A.C., Goos-Nilsson, A., Gullberg, H., Harris, P.K., Heasley, S.E., Hegen, M., Hromockyj, A.E., Hu, X., Husman, B., Janosik, T., Jones, P., Kaila, N., Kallin, E., Kauppi, B., Kiefer, J.R., Knafels, J., Koehler, K., Kruger, L., Kurumbail, R.G., Kyne Jr., R.E., Li, W., Lofstedt, J., Long, S.A., Menard, C.A., Mente, S., Messing, D., Meyers, M.J., Napierata, L., Noteberg, D., Nuhant, P., Pelc, M.J., Prinsen, M.J., Rhonnstad, P., Backstrom-Rydin, E., Sandberg, J., Sandstrom, M., Shah, F., Sjoberg, M., Sundell, A., Taylor, A.P., Thorarensen, A., Trujillo, J.I., Trzupek, J.D., Unwalla, R., Vajdos, F.F., Weinberg, R.A., Wood, D.C., Xing, L., Zamaratski, E., Zapf, C.W., Zhao, Y., Wilhelmsson, A., Berstein, G.
J. Med. Chem.
HeaderSignaling Protein
Released2018-03-07
Resolution2.450
CATH Insert Date09 Sep, 2018

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 09 Sep, 2018 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
6cn6A00 10 Sep, 2018 1.10.565.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma